04940587 is referenced by 122 patents and cites 7 patents.

An arrangement is provided for the application of an oral pharmaceutical to the mucosa of the oral or nasal cavity, for sustained release there of the drug. The arrangement of the invention comprises a body which has a size and shape suitable for insertion into and retention in the oral or nasal cavity, the body being formed of granules of a higher aliphatic alcohol and a hydrated water soluble hydroxyalkyl cellulose having the drug distributed therethrough. This body is coated with a cellulose derivative which is adherent to the mucosa. As a consequence, upon insertion into the oral or nasal cavity, the body adheres to the mucosa and the drug is there slowly released and absorbed into the body. The arrangement is preferably in the form of a buccal tablet, particularly a kidney shaped buccal tablet. Any drug suitable for oral administration can be used, morphine being preferred. The cellulose derivative which is preferred is hydroxypropyl cellulose. The higher aliphatic alcohol is preferably cetostearyl alcohol, and the water soluble cellulose is preferably hydroxyethyl cellulose.

Title
Oral pharmaceutical composition through mucosa
Application Number
6/870027
Publication Number
4940587
Application Date
June 3, 1986
Publication Date
July 10, 1990
Inventor
Ronald B Miller
Basel
CH
Stewart T Leslie
Cambridge
GB
Anthony W Jenkins
Cambridge
GB
Agent
Steinberg & Raskin
Assignee
Euroceltique
LU
IPC
A61F 9/02
A61K 9/36
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