04938763 is referenced by 507 patents and cites 21 patents.

A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

Title
Biodegradable in-situ forming implants and methods of producing the same
Application Number
7/252645
Publication Number
4938763
Application Date
October 3, 1988
Publication Date
July 3, 1990
Inventor
David P Vanderbilt
1049-D Beacon Parkway East, Birmingham, 35204
AL, US
Donald R Cowsar
4657 Round Forest Dr., Birmingham, 35213
AL, US
James P English
2500 Melinda Cir., Birmingham, 35214
AL, US
Richard L Dunn
451 Boardwalk Dr. RLD, Apt. 501, Fort Collins, 80526
CO, US
Agent
Needle & Rosenberg
IPC
A61K 9/22
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