04935345 is referenced by 405 patents and cites 4 patents.

A biochemical sensor is provided for measuring the concentration of a chemical dissolved within a fluid by providing a differential voltage proportional to a temperature differential resulting from the heat evolved from the enzymatic reaction of the chemical under test. The biochemical sensor is formed by depositing thin films of two dissimilar metals upon a substrate using microelectronic fabrication techniques. A multiplicity of thermocouple junctions are created at the intersections of the two dissimilar metal films, and the resulting series-connected thermocouple junctions are alternately designated sensing and reference junctions. The sensing junctions, but not the reference junctions, are covered by an enzyme, catalyst, or other species for initiating a chemical reaction involving the chemical under test, giving rise to a temperature differential between the sensing and reference junctions proportional to the concentration of the chemical under test. The biochemical sensor may be implanted within a human body for continuously monitoring concentrations of glucose or other chemicals present within the bloodstream.

Title
Implantable microelectronic biochemical sensor incorporating thin film thermopile
Application Number
641566
Publication Number
4935345
Application Date
December 30, 1987
Publication Date
June 19, 1990
Inventor
Bruce C Towe
Mesa
AZ, US
Eric J Guilbeau
Tempe
AZ, US
Agent
Cahill Sutton & Thomas
Assignee
Arizona Board of Regents
AZ, US
IPC
A61B 5/05
C12Q 1/54
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