04925268 is referenced by 396 patents and cites 16 patents.

Fiber-optic sensors suitable for monitoring physiological analyte concentration. An analyte-permeable matrix is disposed in the light path defined by the axial core at one end of an optical fiber segment. The matrix contains an indicator molecule covalently linked to a polymer, preferably methyl methacrylate/methacrylamidopropyltrimethylammonium chloride, N-vinylpyrrolidone/p-aminostyrene, methyl methacrylate/hydroxymethyl methacrylate, methyl methacrylate/N-vinylpyrrolidone, or methyl methacrylate/acrylic acid. In representative embodiments, the polymer is approximately 94:6 mole/mole percent of either methyl methacrylate/methacrylamidopropyltrimethylammonium chloride or N-vinylpyrrolidone/p-aminostyrene copolymer. Drift-free performance is obtained with such sensors having analyte-permeable matrices of significantly less than about 70 microns in thickness. The indicator molecule may be covalently linked to the polymer through an aminoarylalkylamine, such as 4-(aminophenyl)-ethylamine or 4-(aminophenyl)-propylamine.

Title
Fiber-optic physiological probes
Application Number
7/224620
Publication Number
4925268
Application Date
July 25, 1988
Publication Date
May 15, 1990
Inventor
Kenneth S Lyon
Seattle
WA, US
Jeffrey B Yim
Woodinville
WA, US
Lokanathan M Iyer
Seattle
WA, US
Agent
Christensen O Connor Johnson & Kindness
Assignee
Abbott Laboratories
IL, US
IPC
G02B 6/02
G02B 6/00
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