04923696 is referenced by 20 patents and cites 1 patents.

The present invention is based on the discovery that amyotrophic lateral sclerosis (ALS), Parkinson disease and Alzheimer disease are due to lack of disorder-specific neurotrophic factors. Specific neurotrophic factors of .about.20-22 kD and .about.16-18 kD have been isolated from rat and human skeletal motor neurons, respectively, and purified. With tissue culture, the presence or absence of the specific neurotrophic factors provided herein can be assessed in ALS. If there is a deficiency, extracted and purified neurotrophic factors specific to the motor neuronal network or system can be administered to ALS-affected individuals.

Title
Method to prepare a neurotrophic composition
Application Number
444293
Publication Number
4923696
Application Date
April 22, 1988
Publication Date
May 8, 1990
Inventor
Kenneth W Vaca
Houston
TX, US
McManaman James L
Kingwood
TX, US
Stanley H Appel
Houston
TX, US
Agent
Davis Hoxie Faithfull & Hapgood
Assignee
Baylor College of Medicine
TX, US
IPC
A61K 37/02
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