04917888 is referenced by 134 patents and cites 3 patents.

A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble or not readily soluble in water at pH 6-8 without such solubilizing agent, is selectively conjugated to a water-soluble polymer selected from polyethylene glycol homopolymers or polyoxyethylated polyols.

Title
Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
Application Number
749955
Publication Number
4917888
Application Date
December 11, 1987
Publication Date
April 17, 1990
Inventor
Michael J Knauf
Oakland
CA, US
Nandini Katre
El Cerrito
CA, US
Agent
Albert P Halluin
Philip L McGarrigle
Janet E Hasak
Assignee
Cetus Corporation
CA, US
IPC
A61K 31/745
A61K 39/44
View Original Source