04902502 is referenced by 130 patents and cites 8 patents.

The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase it solubility, and increase its circulating in vivo half-life.

Title
Preparation of a polymer/interleukin-2 conjugate
Application Number
7/299235
Publication Number
4902502
Application Date
January 23, 1989
Publication Date
February 20, 1990
Inventor
Lois Aldwin
San Mateo
CA, US
Robert J Goodson
Albany
CA, US
Nandini Katre
El Cerrito
CA, US
Danute E Nitecki
Berkeley
CA, US
Agent
Albert P Halluin
Philip L McGarrigle
Assignee
Cetus Corporation
CA, US
IPC
A61K 37/00
A61K 39/00
A61K 31/74
A61K 31/745
View Original Source