04898734 is referenced by 180 patents and cites 14 patents.

The present invention is a method to produce novel composites based on microcapsules or microspheres embedded in contiuous polymeric matrices. Both non-bioerodible and erodible polymers can be used. Material can be incorporated into the microcapsules or microspheres for subsequent release. In one embodiment of the present invention, spheres are homogeneously dispersed in a polymer matrix and then forced to release their contents by exposure to temperature, light or ultrasound. Alternatively, polymers which degrade as a function of time or hydrolysis can be used for controlled releases. The polymer composites have completely different properties from either a continuous polymer matrix or microcapsules or microspheres and are therefore useful for a wide variety of applications. When carbon tetrachloride is the incorporated material, the film is useful as a flame retarding device. When foaming agents are used, especially UV or heat sensitive materials, gas can be evolved inside each capsul

The Government has rights in this invention pursuant to Grant Number 5-R01-GM26698 awarded by the Department of Health and Human Services.

Title
Polymer composite for controlled release or membrane formation
Application Number
7/162161
Publication Number
4898734
Application Date
February 29, 1988
Publication Date
February 6, 1990
Inventor
Elazar Edelman
Brookline
MA, US
Abraham Warshawsky
Rehovot
IL
Robert S Langer
Somerville
MA, US
Edith Mathiowitz
Brookline
MA, US
Agent
Kilpatrick & Cody
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61F 2/00
View Original Source