04892538 is referenced by 320 patents and cites 11 patents.

Methods and devices are disclosed for the delivery of a neurotransmitter from an implanted, neurotransmitter-secreting cell culture to a target region in a subject. The cell culture is maintained within a biocompatible, semipermeable membrane which permits the diffusion of the neurotransmitter therethrough while excluding viruses, antibodies, and other detrimental agents present in the external environment from gaining access. Implantable cell culture devices are disclosed, some of which may be retrieved from the subject, replaced or recharged with new, neurotransmitter-secreting cell cultures, and reimplanted.

Title
In vivo delivery of neurotransmitters by implanted, encapsulated cells
Application Number
7/121626
Publication Number
4892538
Application Date
November 17, 1987
Publication Date
January 9, 1990
Inventor
Pierre M Galletti
Providence
RI, US
Shelley R Winn
Providence
RI, US
Patrick Aebischer
Providence
RI, US
Agent
Ann Louise Kerner
Thomas J Engellenner
Assignee
Brown University Research Foundation
RI, US
IPC
A61K 9/22
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