04891225 is referenced by 154 patents and cites 29 patents.

A novel hydrophobic polymeric matrix is provided which is suitable for use after implantation in vivo in a subject for the controlled release and delivery of biologically active substances such as drugs, antibiotics, steroids and the like. Alternatively, the matrix can be used outside the body for release of fragrances, pesticides and the like. The implantable matrix comprises a polymeric polyanhydride formulation whose internal anhydride linkages are hydrolytic in nature in varying degrees in accordance with the chemical composition of the backbone, pH and temperature of the environment. As the individual anhydride linkages become hydrolyzed, the matrix erodes predominantly by surface erosion into non-toxic biocompatible degradation products with concomitant release of the biologically active substance.

Title
Bioerodible polyanhydrides for controlled drug delivery
Application Number
477710
Publication Number
4891225
Application Date
January 21, 1986
Publication Date
January 2, 1990
Inventor
Howard Rosen
Montara
CA, US
Robert S Langer
Somerville
MA, US
Agent
Kilpatrick & Cody
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61K 31/78
A61F 5/46
A61M 31/00
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