04888176 is referenced by 104 patents and cites 1 patents.

A bioerodible controlled drug release device is produced as a homogeneous polymeric matrix from a high molecular weight polyanhydride and a suitable biologically active substance. The high molecular weight polyanhydride is defined by a molecular weight greater than 20,000 and an intrinsic viscosity greater than 0.3 dl/g. The controlled drug release device is preferrably formed by solvent casting with the biologically active substance and exhibits zero order release, improved correlation between the rate of release and polymer degradation, and an induction period between introduction to the eroding environment and the initial release of the biologically active substance. The controlled drug release devices are stable for extended periods of time, flexible and durable and not subject to fracture and disintegration.

Title
Controlled drug delivery high molecular weight polyanhydrides
Application Number
477710
Publication Number
4888176
Application Date
June 12, 1987
Publication Date
December 19, 1989
Inventor
Cato T Laurencin
Cambridge
MA, US
Abraham J Domb
Brookline
MA, US
Robert S Langer
Sommerville
MA, US
Agent
Kilpatrick & Cody
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61K 31/74
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