04885076 is referenced by 89 patents and cites 4 patents.

A system and method for analyzing molecular constituents of a composition sample includes: forming a solution of the sample, separating the solution by capillary electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5-100 KVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g., .+-.2-8 KVDC) between the eluent at the capillary exit and a cathode spaced in front of the exit. A complete electrical circuit is formed by a conductor which directly contacts the eluent at the capillary exit, or by conduction through a sheath electrode discharged in an annular sheath flow about the capillary exit.

Title
Combined electrophoresis-electrospray interface and method
Application Number
7/178046
Publication Number
4885076
Application Date
April 5, 1988
Publication Date
December 5, 1989
Inventor
Jose A Olivares
North Augusta
SC, US
Harold R Udseth
Richland
WA, US
Richard P Smith
Richland
WA, US
Agent
Marger & Johnson
Assignee
Battelle Memorial Institute
WA, US
IPC
B01D 59/44
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