A containment device for sealing and protecting containers of biological materials. The device comprises a resilient cushion of aqueous fluid sorbent material having a plurality of openings. Each opening is adapted for receiving a respective container of biological material, and the openings are arranged such that each opening is surrounded by sufficient sorbent material to sorb leakage of biological material from its respective container if the container and/or if any additional containers break. The device also includes a case of aqueous fluid resistant material for receiving and enveloping the fluid sorbent material. The case includes two generally stiff-flexible portions having parts adapted for complementary interengagement and adapted to receive means for sealing the portions together to form an air and fluid tight package.