04857311 is referenced by 111 patents and cites 1 patents.

Polyanhydrides with uniform distribution of alkyl and aromatic residues are prepared by melt polycondensation or solution polymerization of p-carboxyphenoxyalkanoic acids or p-carboxyphenylalkanoic acids. These polymers are soluble in common organic solvents and have low melting points, generally in the range of 40.degree.-100.degree. C.

The polyanhydrides are especially well suited for forming bioerodible matrices in controlled bioactive compound delivery devices. A polymeric matrix formed according to the method described here degrades uniformly during drug release, preventing the wholescale channeling of the bioactive compound into the environment, and eliminating the problem of the presence of the polymer matrix at the site long after drug release. The polymer displays zero-order kinetic degradation profiles over various periods of time (days to months), at a rate useful for controlled drug delivery. Furthermore, a desired degradation rate may be obtained by choosing the appropriate length of the aliphatic moiety.

Title
Polyanhydrides with improved hydrolytic degradation properties
Application Number
7/80631
Publication Number
4857311
Application Date
July 31, 1987
Publication Date
August 15, 1989
Inventor
Robert S Langer
Somerville
MA, US
Abraham J Domb
Brookline
MA, US
Agent
Kilpatrick & Cody
Assignee
Massachusetts Institute of Technology
MA, US
IPC
C08G 63/00
A61K 31/74
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