The driver is disclosed for a surgical micro-suturing stapling system which does not require the use of a staple bending anvil tha must be retracted after the staple is implanted. The surgical microstapler system utilizes a unique stapler head comprising a staple magazine having a series of staples attached to and supported by a surrounding frame, apparatus for advancing the staple magazine so as to position its leading staple in a predetermined dispensing position, and staple driving apparatus for implanting the leading staple into the tissue through the ejection slot. The stapler head is adapted to be connected to the driver which provides the driving force required to cause the staple driving apparatus to separate the leading staple from the magazine and implant it into the tissue to be sutured. The driver offers the advantage that can cause the staple driving apparatus to implant a staple at a velocity in excess of the ability of tissue to respond dynamically under the force of a staple being implanted. The driver also is manually powered, can be operated by one hand of the surgeon, has little or no recoil, is simple in operation, and is readily attached to or detached from the stapler head.