04818763 is referenced by 12 patents and cites 6 patents.

Biologically active substance with standardizable hormonal activity, containing in a physiological medium at least one histone, particularly at least one histone H2 or an active area of said histone with immune system immunostimulating and/or endocrinological properties. Utilization of histones and/or segments of histones for producing such a preparation for medical purposes. Said histones may be extracted from biological starting materials, for example calf thymus. Since H2A and H2B histones of oxen and humans are identical, ox histones may also be used for such a preparation for human medical purposes. The preparation according to the present invention may also contain only the variable evolution segments or part of at least one H2 histone. The invention is based on the fact that the biologically active area of an immunostimulating or endocrinologically active histone is located in the variable evolution histone segment. The preparation according to the present invention may be used in immunotherapy.

Title
Biologically active substance with hormonal properties, production process thereof and utilization of histones for medical purposes
Application Number
6/777783
Publication Number
4818763
Application Date
September 12, 1985
Publication Date
April 4, 1989
Inventor
Hans Jornvall
Sundbyberg
SE
Michael Zeppezauer
Saarbrucken-Scheidt
DE
Robert Reichhart
Homburg/Saale
DE
Volker Rusch
Schwalbenweg 6, 6348 Herborn
DE
Agent
Weiser & Stapler
Assignee
Volker Rusch
DE
IPC
A61K 37/48
A61K 37/00
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