04816397 is referenced by 816 patents and cites 9 patents.

Multichain polypeptides or proteins and processes for their production in cells of host organisms which have been transformed by recombinant DNA techniques. According to a first aspect of the present invention, there is provided a process for producing a heterologous multichain polypeptide or protein in a single host cell, which comprises transforming the host cell with DNA sequences coding for each of the polypeptide chains and expressing said polypeptide chains in said transformed host cell. According to another aspect of the present invention there is provided as a product of recombinant DNA technology an Ig heavy or light chain or fragment thereof having an intact variable domain. The invention also provides a process for increasing the level of protein expression in a transformed host cell and vectors and transformed host cells for use in the processes.

Title
Multichain polypeptides or proteins and processes for their production
Application Number
6/672265
Publication Number
4816397
Application Date
November 14, 1984
Publication Date
March 28, 1989
Inventor
Clive R Wood
Near Fordingbridge
GB
John S Emtage
High Wycombe
GB
John H Kenten
High Wycombe
GB
Michael A Boss
Slough
GB
Agent
Cushman Darby & Cushman
Assignee
Celltech
GB
IPC
C12N 1/20
C12N 1/00
C12N 15/00
C12P 21/00
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