04816339 is referenced by 345 patents and cites 5 patents.

Biologically compatible materials capable of being formed into implants, comprising layers of poly(tetrafluoroethylene) and mixtures of poly(tetrafluoroethylene) and elastomer, having excellent compliance, strength, elasticity and suturability are disclosed. The materials are preferably prepared as implants or vascular grafts by co-extruding a relatively thin luminal layer of poly(tetrafluoroethylene) having a distinct fibral nodal microstructure within a layer of a mixture of poly(tetrafluoroethylene) and elastomer to impart elasticity to the implant. A preferred embodiment comprises a radially asymmetric composite vascular graft having a luminal layer of poly(tetrafluoroethylene), a second layer of poly(tetrafluoroethylene)/elastomer mixture, a third layer of elastomer, and a fourth layer of a monomer fibrous elastomer matrix with each layer having a distinctive pore size, pore shape and porosity to promote tissue ingrowth and periprosthetic tissue anchoring.

Title
Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation
Application Number
7/43326
Publication Number
4816339
Application Date
April 28, 1987
Publication Date
March 28, 1989
Inventor
Edwin Wang
Irvine
CA, US
Roger H Tu
Lake Forest
CA, US
Agent
W Dennis Drehkoff
Richard L Myers
Michael C Schiffer
Assignee
Baxter International
IL, US
IPC
A61F 1/24
View Original Source