04803168 is referenced by 69 patents and cites 10 patents.

Disclosed is a process for damage-free encapsulation of a variety of core materials including viable cells. The core material is suspended in an aqueous solution of a polymeric material containing cationic groups such as an aminated glucopolysaccharide, e.g. chitosan. A temporary matrix is formed by gelling droplets of the suspension with a divalent or multivalent anion. The temporary matrix is permanently cross-linked with a polymeric material containing plural anionic groups, e.g., polyaspartic or polyglutamic acid, to form a semipermeable membrane. The interior of the microcapsule may be resolublized by subjecting the capsule to a solution of low molecular weight cations. The process produces microcapsules which are not sticky, do not clump and allow viable cell growth and proliferation.

Title
Microencapsulation with polymers
Application Number
528395
Publication Number
4803168
Application Date
June 4, 1986
Publication Date
February 7, 1989
Inventor
Allan P Jarvis Jr
Newburyport
MA, US
Agent
Lahive & Cockfield
Assignee
Damon Biotech
MA, US
IPC
C12N 5/00
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