04793825 is referenced by 278 patents and cites 23 patents.

A medical implant for injecting into the vascular system of animals comprises a device less than 500 .mu.m in size carrying signal processing means for providing an output in response to an input signal. The input may be acoustic, electromagnetic, temperature, pH value, or chemical. The output may be acoustic, electromagnetic, or chemical. Large numbers, e.g., 10.sup.8, of the implant devices may be mixed into a saline solution and injected into a blood vessel where they are carried around the vascular system, or the devices may be mixed with a gas and inhaled. The amount of circulation depends on the device size. For the larger device e.g., above 7 .mu.m to around 250 .mu.m, circulation will be short lived. Smaller sized e.g., <3 .mu.m devices will circulate for a considerable time. Anti-bodies may be coated onto the devices to cause them to adhere to target areas such as tumors. In one device a chemical is released when illuminated externally by an acoustic beam. In another device a chemical is released when the pH of surrounding blood changes to a given level. Power to operate the device may be by an integral battery.

Title
Active silicon implant devices
Application Number
6/774691
Publication Number
4793825
Application Date
September 11, 1985
Publication Date
December 27, 1988
Inventor
John C White
Lincoln
GB
Adrian L Mears
Cheltenham
GB
John D Benjamin
Malvern
GB
Agent
Cushman Darby & Cushman
Assignee
The Secretary of State for Defence in Her Britannic Majesty s Government of the United Kingdom and Northern Ireland
GB
IPC
A61M 1/00
View Original Source