04766106 is referenced by 301 patents and cites 22 patents.

A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is .beta.-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is not water-soluble or not readily soluble in water at pH 6-8 without such solubilizing agent, is selectively conjugated to a water-soluble polymer selected from polyethylene glycol homopolymers or polyoxyethylated polyols.

Title
Solubilization of proteins for pharmaceutical compositions using polymer conjugation
Application Number
749955
Publication Number
4766106
Application Date
January 25, 1988
Publication Date
August 23, 1988
Inventor
Michael J Knauf
Oakland
CA, US
Nandini Katre
El Cerrito
CA, US
Agent
Janet E Hasak
Albert P Halluin
Assignee
Cetus Corporation
CA, US
IPC
C07K 13/00
A61K 37/02
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