04757128 is referenced by 129 patents and cites 7 patents.

High molecular weight polyanhydrides, defined as polyanhydrides having a molecular weight average greater than 20,000 or an intrinsic viscosity of greater than 0.3 dl/g in an organic solvent at room temperature, are formed by melt polycondensation of highly pure isolated prepolymers under optimized reaction conditions, particularly time and temperature with removal of the condensation product. Higher molecular weights are obtained by inclusion of a catalyst with the prepolymers in the melt polymerization. Catalysts used for transterification, ring opening polymerization and related polymerizations may be utilized.

The high molecular weight polyanhydrides have improved physico-mechanical properties and are especially well suited for biomedical applications, particularly in controlled release devices for drug delivery.

Title
High molecular weight polyanhydride and preparation thereof
Application Number
6/892809
Publication Number
4757128
Application Date
August 1, 1986
Publication Date
July 12, 1988
Inventor
Robert S Langer
Somerville
MA, US
Abraham J Domb
Brookline
MA, US
Agent
Kilpatrick & Cody
Assignee
Massachusetts Institute of Technology
MA, US
IPC
C08G 63/00
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