04753945 is referenced by 51 patents and cites 12 patents.

A method and preparation for the stimulation of tear secretion. The method involves topically applying a phosphodiesterase inhibitor and/or cyclic nucleotide analogue to the ocular surface. Inhibition of phosphodiesterase and cyclic nucleotide analogues increase cyclic nucleotide levels in lacrimal gland tissue, thereby stimulting tear secretion. The preparation contains a phosphodiesterase inhibitor or a cyclic nucleotide analogue and a vehicle for the phosphodiesterase inhibitor or cyclic nucleotide analogue, and may contain an ophthalmic preservative.

Title
Stimulation of tear secretion with phosphodiesterase inhibitors
Application Number
6/830997
Publication Number
4753945
Application Date
February 19, 1986
Publication Date
June 28, 1988
Inventor
Darlene A Dartt
Newton
MA, US
Jeffrey P Gilbard
Boston
MA, US
Agent
Lahive & Cockfield
Assignee
Eye Research Institute of Retina Foundation
MA, US
IPC
A61K 31/52
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