04729961 is referenced by 5 patents and cites 17 patents.

A process for the detection and assay of a biological substance by erythroadsorption by immobilizing a substance having a binding affinity for the biological substance to be assayed; incubating the immobilized substance with a liquid medium containing the biological substance to be assayed, forming a fixed substance; incubating the fixed substance with a coupling product comprising a specific ligand and a second ligand which binds with erythrocytes; adding erythrocytes; and determining the amount of erythrocytes bound to the coupling product. The determination of the amount of bound erythrocytes can be made visually with the naked eye or determined by lysis of the erythrocytes bound to the coupling product and quantitatively measuring the released hemoglobin. The specific ligand can be an antibody or an antigen and the second ligand capable of coupling erythrocytes can, for example, be red blood cell antibodies.

Title
Process for the detection and assay by erythroadsorption
Application Number
355744
Publication Number
4729961
Application Date
December 11, 1985
Publication Date
March 8, 1988
Inventor
Jean Luc Guesdon
Paris
FR
Stratis Avrameas
La Celle Saint Cloud
FR
Agent
Frost & Jacobs
Assignee
Institut Pasteur
FR
IPC
G01N 33/555
G01N 33/566
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