04727064 is referenced by 266 patents and cites 13 patents.

The invention comprises pharmaceutical preparations consisting generally of a drug with a substantially low water solubility and an amorphous, water-soluble cyclodextrin-based mixtures. In these preparations a stable amorphous state can be achieved. This improves the dissolution properties of the drug and hence its absorption by the body. The required cyclodextrin-based mixtures were prepared from .alpha.-, .beta.-, or .gamma.-cyclodextrin which were rendered amorphous through non-selective alkylation. The alkylation agents suitable for that purposes are exemplified by propylene oxide, glycidol, iodoacetamide, chloroacetate, or 2-diethylaminoethylchloride; their reactions with cyclodextrins were performed in a manner to yield mixtures containing many components, a circumstance which effectively prevents crystallization processes within the above pharmaceutical preparation.

Title
Pharmaceutical preparations containing cyclodextrin derivatives
Application Number
603839
Publication Number
4727064
Application Date
May 29, 1985
Publication Date
February 23, 1988
Inventor
Josef Pitha
Baltimore
MD, US
Agent
John S Roberts Jr
Assignee
The United States of America represented by the Department of Health and Human Services
DC, US
IPC
C08B 37/16
A61K 31/70
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