04721669 is referenced by 44 patents and cites 2 patents.

This invention concerns a coordination complex and salts and optically resolved enantiomers thereof, of the formula (R).sub.3 --M, wherein R comprises 1,10-phenanthroline or a substituted derivative thereof, M comprises a suitable transition metal, e.g. ruthenium(II) or cobalt(III), and R is bonded by M by a coordination bond.

The complexes of this invention are useful in methods for labeling, nicking and cleaving DNA. The lambda enantiomer of complexes of this invention is useful in methods for specifically labeling, detecting, nicking and cleaving Z-DNA.

The complexes may also be used in a method for killing tumor cells and may be combined with a pharmaceutically acceptable carrier to form a pharmaceutical composition for the treatment of tumor cells in a subject. The invention further concerns methods for treating a subject afflicted with tumor cells.

Title
Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
Application Number
6/693023
Publication Number
4721669
Application Date
January 18, 1985
Publication Date
January 26, 1988
Inventor
Jacqueline K Barton
New York
NY, US
Agent
John P White
Assignee
The Trustees of Columbia University in the City of New York
NY, US
IPC
A61K 33/24
C07D 471/04
C07H 21/00
C12Q 1/68
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