An improved frame assembly for doors, windows and the like is disclosed. A frame receives a central panel which defines an edge about its exterior perimeter. The frame comprises a first and second skins in opposed relationship defining a cavity therebetween. The interior edge of the frame has internal support ribs which act in conjunction with the interior edge of the frame to grip the edge of the central panel while the exterior edges of the skins are separated by a sizable insert. The cavity between the skins is filled with a foamable insulating material which surrounds the edge of the central panel and forms a weathertight seal.