04699784 is referenced by 244 patents and cites 5 patents.

A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.

Title
Tumoricidal methotrexate-antibody conjugate
Application Number
6/833204
Publication Number
4699784
Application Date
February 25, 1986
Publication Date
October 13, 1987
Inventor
Milton D Goldenberg
Short Hills
NJ, US
Frederick J Primus
Pittstown
NJ, US
Lisa B Shih
Cedar Grove
NJ, US
Agent
Bernhard D Saxe
Assignee
Center for Molecular Medicine & Immunology
NJ, US
IPC
C07K 15/00
A61K 37/44
A61K 31/705
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