04696949 is referenced by 39 patents and cites 1 patents.

The invention provides novel compounds of the formula: ##STR1## wherein n is 0 to 4, R.sub.1 and R.sub.2, which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or methoxymethoxy; R.sub.3 is H, OH, halogen, alkoxy of 1 to 4 carbon atoms, benzyloxy, methoxymethoxy, 2,3-dihydroxypropoxy or ##STR2## wherein m is 1 or 2, R.sub.6 and R.sub.7, which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, or ##STR3## can form an N-containing three-, four-, five- or six-membered heterocyclic ring; R.sub.4 is OH, F, Cl, Br, I, mesyloxy, tosyloxy, alkylcarbonyloxy of 1 to 4 C-atoms, formyloxy or CH.sub.2 R.sub.4 is replaced by CHO; R.sub.5 is H or OH; or R.sub.4 and R.sub.5 together form an --O-- bridge between the carbon atoms to which they are attached, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof. Processes for the preparation of these compounds are described, and also novel pharmaceutical compositions containing them. These compounds exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, and progestanic agents. They are also effective against oestrogen-dependent tumors. Certain compounds are useful as chemical intermediates for the preparation of pharmacologically active compounds of the invention.

Title
Novel tri-phenyl alkane and alkene derivatives and their preparation and use
Application Number
497813
Publication Number
4696949
Application Date
January 29, 1986
Publication Date
September 29, 1987
Inventor
Hannu K Sunduiqst
Kaarina
FI
Guillermo L Blanco
Oulu
FI
Lauri V M Kangas
Turki
FI
Marja Liisa Soderwall
Oulu
FI
Kauko O A Kurkela
Oulu
FI
Arto J Karjalainen
Oulu
FI
Reijo J Toivola
Oulu
FI
Agent
Armstrong Nikaido Marmelstein & Kubovcik
Assignee
Farmos Group
FI
IPC
C07C 91/06
A61K 31/135
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