04690973 is referenced by 10 patents and cites 5 patents.

This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.

Title
Production process of an antithrombogenic and antiadhesive material for medical use
Application Number
6/885782
Publication Number
4690973
Application Date
July 15, 1986
Publication Date
September 1, 1987
Inventor
Hiraku Ito
Kyoto
JP
Takeaki Miyamoto
Nagaokakyo
JP
Teruo Miyata
Tokyo
JP
Masayasu Furuse
Sagamihara
JP
Kazuhiko Kodaira
Mitaka
JP
Yasuharu Noishiki
Tottori
JP
Agent
Sherman and Shalloway
Assignee
Koken Company
JP
IPC
C08L 89/06
C08L 89/04
C08H 1/06
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