04680268 is referenced by 547 patents and cites 22 patents.

The present invention relates to a novel implantable biosensor and method for sensing products, such as hydrogen peroxide, generated from an enzymatic reaction between an analyte, like glucose, and an enzyme in the presence of oxygen. The novel implantable biosensor is uniquely equipped with an enclosed chamber for containing oxygen and can be adapted for extracting oxygen from animal tissue adjacent the container. The reservoir of oxygen contained in the enclosed chamber is supplied to the enzymatic reaction from the side of the membrane opposite the enzyme. The enclosed chamber is uniquely designed to be impermeable to substances, like liquid and cells, that possibly can interfere with the supply of the oxygen permeating through the membrane to the enzymatic reaction. Also, the implantable biosensor is designed to optically or electrically sense products generated from the enzymatic reaction which serve as a function of the analyte.

Title
Implantable gas-containing biosensor and method for measuring an analyte such as glucose
Application Number
6/777234
Publication Number
4680268
Application Date
September 18, 1985
Publication Date
July 14, 1987
Inventor
Leland Clark Jr
Cincinnati
OH, US
Agent
Wood Herron & Evans
Assignee
Children s Hospital Medical Center
OH, US
IPC
C12M 1/34
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