04640835 is referenced by 346 patents and cites 2 patents.

Derivatives of a nonimmunogenic plasminogen activator which comprises at least one polyalkylene glycol group chemically bonded with at least one coupling agent to amino acid side chains of said plasminogen activator, wherein said polyalkylene glycol has a molecular weight of about 200-20,000 and is unsubstituted or is substituted with one or more alkyl, alkoxy or alkanoyl groups or a mixture thereof.

The plasminogen activator derivatives have an extended circulating life in the mammalian bloodstream and also inhibit the formation of thrombus in the same.

Title
Plasminogen activator derivatives
Application Number
437009
Publication Number
4640835
Application Date
October 28, 1983
Publication Date
February 3, 1987
Inventor
Michiko Igarashi
Musashino
JP
Jun Takatsuka
Kawasaki
JP
Taketoshi Kinoshita
Koshigaya
JP
Tsuguji Nakahara
Tokyo
JP
Kimihiro Shimizu
Yoshikawa
JP
Agent
Oblon Fisher Spivak McClelland & Maier
Assignee
Nippon Chemiphar Company
JP
IPC
C12N 9/72
C12N 9/96
A61K 37/48
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