04609551 is referenced by 256 patents and cites 2 patents.

A process for exposing live cells to a soluble bone protein and transferring the cells into appropriate skeletal sites to initiate or enhance local chondrogenesis or osteogenesis. Isogenic fibroblasts are exposed in vitro to a soluble bone protein capable of stimulating in vitro and/or in vivo a chondrogenic response. The fibroblasts are then transferred in vivo in a manner effective to prevent diffusion away from the implantation site so that the desired chondro/osteogenesis reaction can proceed. Delivery systems include: combining the activated fibroblasts with a biodegradable matrix; suspending the activated fibroblasts in a solution suitable for intra-articular injection; and attaching the fibroblasts to allografts and prosthetic devices.

Title
Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
Application Number
6/591440
Publication Number
4609551
Application Date
March 20, 1984
Publication Date
September 2, 1986
Inventor
Glenn T Syftestad
3660 Warrensville Center Rd. #101, Shaker Heights, 44122
OH, US
Arnold Caplan
1300 Oakridge Dr., Cleveland Heights, 44121
OH, US
Agent
Watts Hoffmann Fisher & Heinke
IPC
A61F 2/28
A61K 35/32
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