04598049 is referenced by 94 patents and cites 15 patents.

A microprocessor controlled, general purpose gene synthesizer for programmably synthesizing selected nucleotide sequences. Depending upon a programmed chemistry, metered volumes of selected bases and reagent/solvents are sequentially metered into the bottom of a reaction cell containing solid-supported nucleotides, where desired linkages are achieved in an agitated suspension. Self-refilling syringe metering and electrically initiated, pneumatically operated valving insures economical, non-contaminated synthesis. Preprogrammed, selectable chemistries and operator programmed sequences are operatively coupled under microprocessor control to ensure a general purpose synthesizer.

Title
General purpose gene synthesizer
Application Number
6/528053
Publication Number
4598049
Application Date
August 31, 1983
Publication Date
July 1, 1986
Inventor
Bruce E Kaplan
Claremont
CA, US
Carl W Sims
St. Paul
MN, US
Keiichi Itakura
Arcadia
CA, US
Richard J Zelinka
Lino Lakes
MN, US
Agent
Thomas J Nikolai
Orrin M Haugen
Assignee
Systec
MN, US
IPC
G05B 17/00
B67D 5/52
C12M 1/36
C12M 1/00
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