04589881 is referenced by 176 patents.

A polypeptide having the cell-attaching activity of fibronectin. The polypeptide has 108 amino acid residues and the formula: H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val-Ala- Ala-Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val-Thr-Val-Arg-Tyr -Tyr-Arg-Ile-Thr-Tyr-Gly-Glu-Thr-Gly-Gly-Asn-Ser-Pro-Val-Gln-Glu-Phe-Thr-Va l-Pro-Gly-Ser-Lys-Ser-Thr-Ala-T r-Ile-Ser-Gly-Leu-Lys-Pro-Gly-Val-Asp-Tyr-Thr-Ile-Thr-Val-Tyr-Ala-Val-Thr- Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-Ile-Ser-Ile-Asn-Tyr-Arg-Thr-Glu -Ile-Asp-Lys-Pro-Ser-Gln-Met-OH. The polypeptide or a biologically active fragment thereof, such as H-Tyr-Ala-Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-Ile-Ser-Ile- Asn-Tyr-Arg-Thr-Glu-Ile-Asp-Lys-Pro-Ser-Gln-Met-OH can be employed in the preparation of substrata designed for the attachment of cells thereto. A Cys-residue may optionally be attached at the C-terminus. It can be linked to the surface of a prosthetic device to particularly attract endothelial cells and fibroblastic cells.

Title
Polypeptide
Application Number
433457
Publication Number
4589881
Application Date
July 28, 1983
Publication Date
May 20, 1986
Inventor
Erkki I Ruoslahti
Olivenhain
CA, US
Michael D Pierschbacher
San Diego
CA, US
Agent
Fulwider Patton Rieber Lee & Utecht
Assignee
La Jolla Cancer Research Foundation
CA, US
IPC
C07G 7/00
C07C 103/52
A61K 37/00
A61F 1/00
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