04562157 is referenced by 229 patents and cites 5 patents.

A device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realized under conditions of miniaturization, the invention makes possible "printed circuits for proteins".

In addition to the device are the process of manufacture thereto, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.

Title
Diagnostic device incorporating a biochemical ligand
Application Number
6/614121
Publication Number
4562157
Application Date
May 25, 1984
Publication Date
December 31, 1985
Inventor
Fergus G P Earley
Solihull
GB
Christopher R Lowe
Newmarket
GB
Agent
Oblon Fisher Spivak McClelland & Maier
Assignee
National Research Development Corporation
GB
IPC
G01N 33/54
C12M 1/34
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