04557934 is referenced by 164 patents and cites 23 patents.

Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at selected levels in combination with certain C.sub.3 -C.sub.4 diols or a 1-substituted azacycloalkyl-2-one. This composition provides marked transepidermal and percutaneous delivery of the selected pharmaceutically-active agent. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.

Title
Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
Application Number
6/506275
Publication Number
4557934
Application Date
June 21, 1983
Publication Date
December 10, 1985
Inventor
Eugene R Cooper
Cincinnati
OH, US
Agent
Jack D Schaeffer
Steven J Goldstein
George W Allen
Assignee
The Procter & Gamble Company
OH, US
IPC
A61K 33/42
A01N 59/26
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