04546500 is referenced by 110 patents and cites 6 patents.

A method and apparatus for producing a vessel-equivalent prosthesis is described. A contractile agent such as fibroblast cells, smooth muscle cells or platelets is incorporated into a collagen lattice and contracts the lattice axially around an inner core. After the structure has set, additional layers may be formed in an ordered manner depending on the intended function of the prosthesis. Alternatively, all the layers may be formed concurrently. A plastic mesh sleeve is sandwiched between layers or embedded within the smooth muscle cell layer to reinforce the structure and provide sufficient elasticity to withstand intravascular pressure.

Title
Fabrication of living blood vessels and glandular tissues
Application Number
261928
Publication Number
4546500
Application Date
February 26, 1982
Publication Date
October 15, 1985
Inventor
Eugene Bell
Dedham
MA, US
Agent
Leo R Reynolds
David E Brook
Arthur A Smith Jr
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61F 1/00
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