04545382 is referenced by 769 patents and cites 16 patents.

A sensor electrode to detect one or more components in a liquid mixture comprises an electrically conductive material having at least an an external surface, the combination of an enzyme catalytic for a reaction of the desired component, and a mediator compound which transfers electrons from the enzyme to the electrode when such catalytic activity takes place. It can be used as an in vivo glucose sensor either with a silver electrode coated with e.g. glucose oxidase and a polyviologen as the mediators, or with a particulate carbon electrode, glucose oxidase and chloranil or fluoranil as mediator. Another system is to use bacterial glucose dehydrogenase or glucose oxidase as the enzyme and/or ferrocene or a ferrocene derivative as the mediators compound to give electrodes with improved linearity, speed of response and insensitivity to oxygen.

Title
Sensor for components of a liquid mixture
Application Number
6/436106
Publication Number
4545382
Application Date
October 22, 1982
Publication Date
October 8, 1985
Inventor
Elliot V Plotkin
Bedford
GB
Hugh A O Hill
Oxford
GB
Irving J Higgins
Wilden
GB
Assignee
Genetics International
MA, US
IPC
A61B 5/00
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