04537776 is referenced by 133 patents and cites 17 patents.

Topical pharmaceutical compositions comprising a pharmaceutically-active agent and a novel, penetration-enhancing vehicle or carrier are disclosed. The vehicle or carrier comprises a binary combination of N-(2-Hydroxyethyl) pyrrolidone and a "cell-envelope disordering compound". The compositions provide marked transepidermal and percutaneous delivery of the active selected. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.

Title
Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
Application Number
6/506273
Publication Number
4537776
Application Date
June 21, 1983
Publication Date
August 27, 1985
Inventor
Eugene R Cooper
Cincinnati
OH, US
Agent
Richard C Witte
Steven J Goldstein
George W Allen
Assignee
The Procter & Gamble Company
OH, US
IPC
A61K 31/40
A01N 43/36
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