04529719 is referenced by 102 patents.

Stroma-free deoxy mammalian tetrameric hemoglobin is crosslinked with certain bis diaspirin esters and modified with pyridoxyl-5'-phosphate followed by reduction to produce bis-diamide covalently crosslinked, pyridoxal-5'-phosphate covalently modified tetrameric hemoglobin wherein the crosslinking and modifying bonds occur in the beta cleft. The modified crosslinked stroma-free tetrameric hemoglobin of this invention is a disease-free, oxygen transporting discrete molecular species, free from cell surface antigens, having use as a substitute for transfusion of red blood cells. This modified crosslinked stroma-free hemoglobin is a stable oxygen carrying protein capable of oxygen delivery to perfused tissue and advantageously remaining in the intravascular space.

Title
Modified crosslinked stroma-free tetrameric hemoglobin
Application Number
6/497454
Publication Number
4529719
Application Date
May 4, 1983
Publication Date
July 16, 1985
Inventor
Ross W Tye
937 B Rosenstock Rd., Sausalito, 94965
CA, US
Agent
Townsend and Townsend
IPC
C07G 7/00
A23J 1/06
A61K 35/14
A61K 37/00
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