04522809 is referenced by 27 patents and cites 7 patents.

A process is disclosed for producing virus sub-units with lipid envelopes, comprising, in a neutral or basic pH, dissolving a lower halogenated hydrocarbon, at a concentration equivalent to or approximating its limit of solubility, in an aqueous virus suspension, thereafter contacting, with stirring, the preparation so obtained with a nonionic detergent at a minimum concentration effective to induce disruption of virions into heavy sub-units for a length of time sufficient to permit said disruption, and in separating the heavy sub-units so obtained from the reaction medium. The process permits preparation of purified disrupted antigens for use as vaccines, notably influenza vaccines.

Title
Process for obtaining lipid envelope virus sub-units, notably antigens for use as vaccines, the products obtained and their applications
Application Number
6/636791
Publication Number
4522809
Application Date
August 1, 1984
Publication Date
June 11, 1985
Inventor
Ludwig Muller
Plessis Robinson
FR
Philippe Adamowicz
Garches
FR
Agent
Frost & Jacobs
Assignee
Institut Pasteur
FR
IPC
A61K 39/145
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