04476590 is referenced by 129 patents and cites 8 patents.

Surgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue. Latently bioerodible silver components of an implant can be activated by, for example, abrasion, heating to above about 180.degree. C. or, especially, contact with hydrogen peroxide.

Title
Antimicrobial surgical implants
Application Number
6/328594
Publication Number
4476590
Application Date
November 23, 1981
Publication Date
October 16, 1984
Inventor
Michael J Wilkinson
Radlett
GB
John T Scales
Stanmore
GB
Agent
Cushman Darby & Cushman
Assignee
National Research Development Corporation
GB
IPC
A61F 1/04
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