04458678 is referenced by 213 patents and cites 4 patents.

This invention relates to the introduction of viable cells into a fibrous lattice by surgical, force-utilizing, or other manipulative techniques, all of which are referred to herein as "seeding." One embodiment comprises an autografting technique which involves intact tissue. Other embodiments which involve the distribution of an aqueous suspension of cells comprise centrifugal, spraying, pipetting and syringe emplacement. Each cell that survives the seeding process may reproduce into a colony of cells which grow until they reach confluence, thereby creating a uniform layer or volume of tissue. By proper placement of cells capable of generating such colonies, the period of recovery of a wound may be drastically reduced. In addition, research by the Applicants indicates that tissue that is regenerated using the methods of this invention to seed a lattice comprising collagen and glycosaminoglycan tends to be smoother, more uniform, less fibrotic, less scarred and more flexible than tissue that is regenerated by wound contraction or conventional autografting.

Title
Cell-seeding procedures involving fibrous lattices
Application Number
6/315233
Publication Number
4458678
Application Date
October 26, 1981
Publication Date
July 10, 1984
Inventor
John F Burke
Belmont
MA, US
Ioannis V Yannas
Newton Center
MA, US
Agent
David E Brook
Arthur A Smith Jr
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61F 13/00
View Original Source