04452775 is referenced by 221 patents and cites 5 patents.

Delivery systems for releasing macromolecular active agents to a body site at a controlled rate for a prolonged period of time, comprising a cholesteric matrix permeable to passage of the macromolecular active agent by diffusion, are disclosed. The cholesteric matrix comprises cholesterol powder and cholesterol prills optionally in combination with a binding agent and a lubricating agent. The macromolecular active agent is dispersed throughout the matrix; macromolecules suitable for release from this delivery system have molecular weights of about 1300 to about 75,000 and are at least very slightly soluble in water.

Title
Cholesterol matrix delivery system for sustained release of macromolecules
Application Number
6/446749
Publication Number
4452775
Application Date
December 3, 1982
Publication Date
June 5, 1984
Inventor
John S Kent
Palo Alto
CA, US
Agent
Alan M Krubiner
Tom M Moran
Ellen J Buckles
Assignee
Syntex
CA, US
IPC
A61K 37/26
A61K 37/02
A61K 31/56
A61K 9/26
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