04442843 is referenced by 198 patents and cites 3 patents.

Microbubbles are formed in a liquid, e.g., blood in order to alter the transmission characteristics thereof to electromagnetic and sonic waves transmitted therethrough, by dissolving therein a solid particulate material, preferably as a suspension in a carrier liquid in which the particulate material is at least temporarily stable, the particles of which are substantially free of microbubbles and have a plurality of gas-filled voids communicating with the surface of the particles and providing nuclei for microbubble formation and the ratio of the mass of the particles to the volume of gas in the voids is sufficient to render the liquid in which the particulate material is dissolved supersaturated with respect to the gas in the voids in the area of the liquid surrounding the microbubbles when they are formed.

Title
Microbubble precursors and methods for their production and use
Application Number
207741
Publication Number
4442843
Application Date
November 17, 1981
Publication Date
April 17, 1984
Inventor
Ernest G Tickner
Gilroy
CA, US
Julia S Rasor
Cupertino
CA, US
Agent
Millen & White
Assignee
Schering
DE
IPC
A61G 10/00
View Original Source