04442655 is referenced by 177 patents and cites 6 patents.

A dry preparation having a foam-like and, respectively, fleece-like structure obtained by freeze-drying consists, apart from thrombin in at least catalytically active amounts, substantially of approx. 10 to 95% by weight of fibrin and approx. 5 to 90% by weight of fibrinogen. For the preparation thereof, fibrin is produced in situ in an aqueous solution containing fibrinogen and thrombin and the resultant reaction mixture is deep-frozen and lyophilized. As further constituents of the dry preparation active substances such as e.g. antibiotics, natural bone material and/or a synthetic, bone-forming substitute, glycoproteins, coagulation-conducive substances and the like and/or fibrinolysis inhibitors come into consideration. The dry preparation is provided mainly for use as a wound toilet material, as a filling material for bone cavities and/or as a supporting material for further active substances.

Title
Fibrinogen-containing dry preparation, manufacture and use thereof
Application Number
6/392215
Publication Number
4442655
Application Date
June 25, 1982
Publication Date
April 17, 1984
Inventor
Michael Stroetmann
Munster
DE
Agent
Gordon W Hueschen
Assignee
Serapharm Michael Stroetmann
DE
IPC
A61K 37/00
A61K 35/14
A61K 9/14
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