04436094 is referenced by 507 patents and cites 4 patents.

A method for the continuous, in vivo measurement of glucose concentration in animal body fluids such as blood, comprises implanting in the body, in registry with the system for the body fluid, a glucose monitor adapted to measure the concentration of glucose as a function of changes in such electrical charge. The glucose monitor includes an electrode with an electrical charge-transfer medium comprising a reversible complex of a binding macromolecular component and a charge-bearing carbohydrate component. The electrode includes a selectively permeable membrane permitting the ingress and egress of the body fluid. In operation, glucose present in the body fluid displaces the charge-bearing carbohydrate, which then participates in the electrical activity of the electrode so that a measurable change in electrical activity can be observed when the electrode is connected to an appropriate current-responsive meter. Preferably, the macromolecular component comprises one or more lectins, and the charge-bearing carbohydrate component may be one or more of the sugars for which testing is desired.

Title
Monitor for continuous in vivo measurement of glucose concentration
Application Number
241991
Publication Number
4436094
Application Date
January 27, 1982
Publication Date
March 13, 1984
Inventor
Anthony Cerami
New York
NY, US
Agent
Daniel H Bobis
David A Jackson
Assignee
Evreka
NJ, US
IPC
G01N 27/30
G01N 33/66
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