04391797 is referenced by 110 patents and cites 12 patents.

Delivery systems manufactured in the form of polymeric compositions for the controlled delivery of macromolecules to environments of use are disclosed. The systems are characterized as two-phase compositions comprising a phase formed of an insoluble polymeric matrix having limited water sorptivity containing in admixture therein an interpenetrating phase formed of a particulate hydrophilic water swellable, biologically active macromolecular material.

Title
Systems for the controlled release of macromolecules
Application Number
756892
Publication Number
4391797
Application Date
August 10, 1981
Publication Date
July 5, 1983
Inventor
Robert S Langer Jr
Allston
MA, US
Moses J Folkman
Brookline
MA, US
Assignee
The Children s Hospital Medical Center
MA, US
IPC
A61K 37/26
A61K 31/74
A61K 9/26
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