04384995 is referenced by 50 patents and cites 12 patents.

Modified hormones or fragments of hormones are useful in producing antibodies when administered to an animal. Said antibodies in turn cause neutralization of endogenous natural protein hormones. The modification may be accomplished by attaching various kinds of modifying groups to the hormone or fragment. Modification may, for example, be achieved by chemically coupling diazosulfanilic acid groups to the hormone or fragment. The protein hormones to which this procedure can be applied are mammalian protein reproductive hormones such as, for example, Follicle Stimulating Hormone (FSH), or Human Chorionic Gonadotropin (HCG). These modified polypeptides may be administered to animals for the purpose of contraception, abortion, or treatment of hormone-related disease states and disorders, including hormone-associated carcinomas.

Title
Antigenic modification of polypeptides
Application Number
357892
Publication Number
4384995
Application Date
November 20, 1981
Publication Date
May 24, 1983
Inventor
Vernon C Stevens
Dublin
OH, US
Agent
Millard & Cox
Assignee
The Ohio State University
OH, US
IPC
A61K 37/00
A61K 39/00
C07C 103/52
View Original Source